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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Jose | C | Winston-Salem Spirits | 22 | 02/16/1982 | Caracas | VEN | Switch | Right | 6' 3" | 200 lbs | - |
| Sampson, Chris | SP | Prince William Cannons | 25 | 05/23/1978 | Channelview | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sandoval, Michael | 3B | Winston-Salem Spirits | 22 | 07/08/1981 | Puerto Cabello | VEN | Right | Right | 5' 11" | 200 lbs | - |
| Santana, Cristobal | LF | Frederick Keys | 22 | 08/23/1981 | Santo Domingo | DOM | Right | Right | 6' 4" | 190 lbs | - |
| Scarbery, Chad | SP | Salem Buccaneers | 23 | 09/23/1980 | Fresno | USA | Right | Right | 6' 1" | 200 lbs | - |
| Schill, Vaughn | 3B | Salem Buccaneers | 26 | 09/10/1977 | Audubon | USA | Right | Right | 6' 2" | 205 lbs | - |
| Schwabe, Ryan | SP | Salem Buccaneers | 22 | 02/24/1982 | Carroll | USA | Left | Left | 6' 3" | 210 lbs | - |
| Seddon, Chris | SP | Frederick Keys | 20 | 10/13/1983 | Los Angeles | USA | Left | Left | 6' 4" | 220 lbs | - |
| Seguro, Winston | 2B | Kinston Guardians | 25 | 07/03/1978 | Unknown | USA | Right | Right | 5' 9" | 150 lbs | - |
| Serrano, Jorge | RP | Free Agent | 26 | 01/25/1978 | Unknown | MEX | Right | Right | 5' 9" | 190 lbs | - |
| Shanks, Eric | SS | Winston-Salem Spirits | 25 | 07/07/1978 | Charlotte | USA | Right | Right | 5' 11" | 185 lbs | - |
| Sheaffer, Jon | CF | Frederick Keys | 24 | 02/08/1980 | Chicago | USA | Right | Right | 6' 1" | 190 lbs | - |
| Shell, Steven | RP | Prince William Cannons | 21 | 03/10/1983 | Longview | USA | Right | Right | 6' 4" | 225 lbs | - |
| Silva, Doug | RP | Free Agent | 23 | 02/07/1981 | Walnut Creek | USA | Right | Right | 6' 0" | 190 lbs | - |
| Simpson, Andre | RP | Durham Bulls | 23 | 07/01/1980 | San Diego | USA | Right | Right | 6' 3" | 185 lbs | - |
| Slack, Jon | CF | Winston-Salem Spirits | 22 | 12/04/1981 | Winchester | USA | Left | Left | 5' 11" | 185 lbs | - |
| Smith, Brett | CF | Salem Buccaneers | 25 | 07/09/1978 | Minneapolis | USA | Switch | Right | 5' 11" | 180 lbs | - |
| Smith, Casey | 1B | Lynchburg Red Sox | 25 | 03/18/1979 | Dothan | USA | Right | Right | 6' 2" | 200 lbs | - |
| Soto, Jesus | RP | Free Agent | 24 | 10/17/1979 | Guaymas | MEX | Right | Right | 6' 1" | 170 lbs | - |
| St. Pierre, Max | C | Peninsula Pilots | 24 | 04/17/1980 | Quebec City | CAN | Right | Right | 6' 0" | 180 lbs | - |
| Stenson, Dernell | LF | Peninsula Pilots | 25 | 06/17/1978 | LaGrange | USA | Left | Left | 6' 1" | 225 lbs | - |
| Stewart, Paul | RP | Peninsula Pilots | 25 | 10/21/1978 | Alexandria | USA | Right | Right | 6' 5" | 200 lbs | - |
| Stults, Eric | SP | Durham Bulls | 24 | 12/09/1979 | Plymouth | USA | Left | Left | 6' 2" | 220 lbs | - |
