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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanchez, Jose Allen | RP | Pulaski Braves | 19 | 05/12/1984 | Maracaibo | VEN | Right | Right | 6' 3" | 180 lbs | - |
| Sanders, Marcus | SS | Martinsville Phillies | 18 | 08/25/1985 | Sarasota | USA | Right | Right | 6' 0" | 165 lbs | - |
| Santana, Rico | LF | Martinsville Phillies | 24 | 12/06/1979 | Unknown | USA | Right | Right | 6' 2" | 205 lbs | - |
| Santos, Sergio | RP | Bluefield Orioles | 20 | 07/04/1983 | Bellflower | USA | Right | Right | 6' 3" | 215 lbs | - |
| Sarabia, Hamilton | LF | Martinsville Phillies | 21 | 06/11/1982 | Unknown | COL | Left | Right | 5' 11" | 185 lbs | - |
| Scott, Bradley | CF | Bluefield Orioles | 26 | 04/22/1977 | Virginia | USA | Right | Right | 5' 11" | 180 lbs | - |
| Seaton, Chris | RP | Pulaski Braves | 25 | 09/22/1978 | Tampa | USA | Right | Right | 6' 0" | 190 lbs | - |
| Segovia, Omar | RP | Free Agent | 20 | 05/28/1983 | Caguas | PUR | Left | Left | 6' 2" | 210 lbs | - |
| Segovia, Zack | RP | Bluefield Orioles | 21 | 04/11/1983 | Dallas | USA | Right | Right | 6' 2" | 245 lbs | - |
| Sellers, Neil | 3B | Martinsville Phillies | 22 | 04/03/1982 | Unknown | USA | Right | Right | 6' 0" | 195 lbs | - |
| Septimo, Agustin | SS | Free Agent | 19 | 05/27/1984 | Santo Domingo | DOM | Left | Right | 5' 11" | 175 lbs | - |
| Serrato, Juan | SP | Kingsport Mets | 22 | 11/04/1981 | Riverside | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sewell, Kevin | 2B | Wytheville Cubs | 23 | 01/28/1981 | Glendale Heights | USA | Left | Right | 5' 11" | 205 lbs | - |
| Silva, Yohan | CF | Free Agent | 19 | 01/30/1985 | Unknown | VEN | Switch | Right | 5' 11" | 175 lbs | - |
| Simmons, Lyndsey | C | Martinsville Phillies | 22 | 10/15/1981 | Santa Monica | USA | Left | Right | 6' 0" | 200 lbs | - |
| Simon, Brandon | CF | Martinsville Phillies | 23 | 09/09/1980 | Fresno | USA | Left | Left | 5' 11" | 190 lbs | - |
| Singleton, Steven | RP | Princeton Pirates | 24 | 06/14/1979 | Unknown | USA | Right | Right | 6' 4" | 235 lbs | - |
| Skelton, James | C | Wytheville Cubs | 18 | 10/28/1985 | West Covina | USA | Left | Right | 5' 11" | 165 lbs | - |
| Slevin, David | 2B | Martinsville Phillies | 22 | 05/23/1981 | Port St. Lucie | USA | Right | Right | 5' 11" | 180 lbs | - |
| Smith, C. | SS | Burlington Guardians | 27 | 05/05/1976 | Unknown | USA | Right | Right | 5' 11" | 180 lbs | - |
| Smith, Donnie | RP | Pulaski Braves | 21 | 01/14/1983 | Hagerstown | USA | Right | Right | 6' 2" | 210 lbs | - |
| Smith, John | 2B | Martinsville Phillies | 22 | 01/18/1982 | Dublin | USA | Left | Right | 5' 10" | 180 lbs | - |
| Smith, Will | LF | Free Agent | 26 | 05/07/1977 | Montgomery | USA | Right | Right | 5' 11" | 185 lbs | - |
| Sobieraj, Aaron | 2B | Johnson City Cardinals | 22 | 06/03/1981 | Buffalo | USA | Right | Right | 6' 2" | 175 lbs | - |
| Socarras, Tony | C | Johnson City Cardinals | 25 | 11/08/1978 | Miami | USA | Left | Right | 6' 0" | 200 lbs | - |
| Solano, Solamdi | 2B | Martinsville Phillies | 20 | 08/18/1983 | San Cristóbal | DOM | Right | Right | 6' 0" | 160 lbs | - |
| Sosa, Ricardo | 3B | Wytheville Cubs | 19 | 05/24/1984 | Unknown | CUB | Right | Right | 6' 1" | 220 lbs | - |
| Soto, Luis | RF | Wytheville Cubs | 18 | 12/07/1985 | Banà | DOM | Switch | Right | 6' 1" | 180 lbs | - |
| Spiehs, R.D. | RP | Bluefield Orioles | 24 | 10/18/1979 | Grand Island | USA | Right | Right | 6' 3" | 225 lbs | - |
| Springer, Kenard | LF | Martinsville Phillies | 20 | 09/18/1983 | Tupelo | USA | Right | Right | 5' 11" | 210 lbs | - |
| Sprowl, Jon-Mark | C | Elizabethton Twins | 23 | 08/01/1980 | Tucson | USA | Left | Right | 6' 1" | 200 lbs | - |
| Stone, David | LF | Free Agent | 24 | 12/30/1979 | Frederick | USA | Left | Right | 6' 2" | 190 lbs | - |
| Stone, Greg | 2B | Martinsville Phillies | 23 | 02/19/1981 | Tulsa | USA | Left | Right | 5' 0" | 180 lbs | - |
| Stout, Danny | RP | Bristol Tigers | 26 | 02/16/1978 | Columbus | USA | Right | Right | 6' 2" | 210 lbs | - |
| Stout, Josh | RP | Kingsport Mets | 22 | 09/07/1981 | Unknown | USA | Right | Right | 6' 3" | 225 lbs | - |
| Stringfellow, Chris | CF | Free Agent | 23 | 11/14/1980 | Fontana | USA | Right | Right | 5' 10" | 170 lbs | - |
| Sullivan, Brad | RP | Pulaski Braves | 22 | 09/12/1981 | Beaumont | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sultemeier, Eric | CF | Wytheville Cubs | 21 | 06/28/1982 | New Braunfels | USA | Right | Right | 6' 2" | 180 lbs | - |
| Surratt, Randy | RP | Pulaski Braves | 22 | 08/17/1981 | Grosse Pointe | USA | Left | Left | 6' 2" | 190 lbs | - |
| Szabo, Jordan | RF | Free Agent | 20 | 08/24/1983 | Mission Viejo | USA | Right | Right | 6' 3" | 195 lbs | - |
| Szabo, Marshall | 2B | Martinsville Phillies | 21 | 02/13/1983 | Alpharetta | USA | Switch | Right | 5' 11" | 180 lbs | - |
