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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 511 | 1890-1911 | |
| 2 | Walter Johnson* | 417 | 1907-1927 | |
| 3 | Grover Cleveland Alexander* | 373 | 1911-1930 | |
| 3 | Christy Mathewson* | 373 | 1900-1916 | |
| 5 | Warren Spahn* | 363 | 1942-1965 | |
| 6 | Kid Nichols* | 361 | 1890-1906 | |
| 7 | Pud Galvin* | 352 | 1875-1892 | |
| 8 | Don Sutton* | 335 | 1966-1990 | |
| 9 | Steve Carlton* | 329 | 1965-1988 | |
| 10 | John Clarkson* | 328 | 1882-1894 | |
| 11 | Tim Keefe* | 325 | 1880-1893 | |
| 12 | Nolan Ryan* | 323 | 1966-1992 | |
| 13 | Phil Niekro* | 318 | 1964-1987 | |
| 14 | Gaylord Perry* | 314 | 1962-1983 | |
| 15 | Tom Seaver* | 311 | 1967-1986 | |
| 16 | Mickey Welch* | 307 | 1880-1892 | |
| 17 | Roger Clemens# | 306 | 1984-2001 | |
| 18 | Eddie Plank* | 305 | 1901-1917 | |
| 19 | Lefty Grove* | 300 | 1925-1941 | |
| 19 | Early Wynn* | 300 | 1939-1963 | |
| 21 | Bobby Mathews | 297 | 1871-1887 | |
| 22 | Robin Roberts* | 286 | 1948-1966 | |
| 23 | Dwight Gooden# | 284 | 1984-2000 | |
| 23 | Fergie Jenkins* | 284 | 1965-1983 | |
| 25 | Jim Kaat* | 283 | 1959-1983 | |
| 26 | Tommy John* | 282 | 1963-1988 | |
| 26 | Charley Radbourn* | 282 | 1880-1891 | |
| 28 | Bert Blyleven* | 273 | 1970-1990 | |
| 28 | Red Ruffing* | 273 | 1924-1947 | |
| 28 | Fernando Valenzuela | 273 | 1980-1999 | |
| 31 | Burleigh Grimes* | 270 | 1916-1934 | |
| 32 | Jack Morris | 268 | 1977-1997 | |
| 32 | Jim Palmer* | 268 | 1965-1984 | |
| 34 | Bob Feller* | 266 | 1936-1956 | |
| 34 | Eppa Rixey* | 266 | 1912-1933 | |
| 36 | Frank Viola | 262 | 1982-1998 | |
| 37 | Ted Lyons* | 260 | 1923-1946 | |
| 38 | Red Faber* | 254 | 1914-1933 | |
| 39 | Carl Hubbell* | 253 | 1928-1943 | |
| 39 | Al Spalding* | 253 | 1871-1878 | |
| 41 | Bob Gibson* | 251 | 1959-1975 | |
| 42 | Rick Reuschel | 250 | 1972-1993 | |
| 43 | Vic Willis | 249 | 1898-1910 | |
| 44 | Tony Mullane | 248 | 1881-1894 | |
| 45 | Bret Saberhagen | 247 | 1984-2000 | |
| 46 | Joe McGinnity* | 246 | 1899-1908 | |
| 47 | Jack Powell | 245 | 1897-1912 | |
| 47 | Amos Rusie* | 245 | 1889-1901 | |
| 49 | Juan Marichal* | 243 | 1960-1975 | |
| 50 | Herb Pennock* | 240 | 1912-1934 | |
| 51 | Jim McCormick | 239 | 1879-1887 | |
| 52 | Doug Drabek# | 237 | 1986-2000 | |
| 52 | Waite Hoyt* | 237 | 1918-1938 | |
| 54 | Whitey Ford* | 236 | 1950-1967 | |
| 54 | Orel Hershiser | 236 | 1983-2000 | |
| 56 | Charlie Hough | 235 | 1970-1992 | |
| 57 | Clark Griffith* | 234 | 1891-1914 | |
| 57 | Gus Weyhing | 234 | 1887-1901 | |
| 59 | Dennis Martinez | 233 | 1976-1997 | |
| 60 | Sam Jones | 229 | 1914-1935 | |
| 60 | Jimmy Key# | 229 | 1984-2001 | |
| 60 | Greg Maddux# | 229 | 1986-2001 | |
| 60 | Luis Tiant | 229 | 1964-1982 | |
| 60 | John Tudor | 229 | 1979-1996 | |
| 60 | Will White | 229 | 1877-1886 | |
| 66 | Kevin Appier# | 224 | 1988-2001 | |
| 66 | Jim Bunning | 224 | 1955-1971 | |
| 66 | Catfish Hunter* | 224 | 1965-1979 | |
| 66 | Randy Johnson# | 224 | 1988-2001 | |
| 70 | Paul Derringer | 223 | 1931-1945 | |
| 70 | Mel Harder | 223 | 1928-1947 | |
| 70 | Joe Niekro | 223 | 1967-1988 | |
| 70 | Dave Stewart | 223 | 1978-1999 | |
| 74 | Hooks Dauss | 222 | 1912-1926 | |
| 74 | Jerry Koosman | 222 | 1967-1985 | |
| 74 | Bob Welch | 222 | 1978-1994 | |
| 77 | Tommy Bond | 221 | 1874-1882 | |
| 77 | David Cone# | 221 | 1986-2001 | |
| 79 | Adonis Terry | 219 | 1884-1897 | |
| 80 | Bob Caruthers | 218 | 1884-1893 | |
| 80 | Earl Whitehill | 218 | 1923-1939 | |
| 82 | Freddie Fitzsimmons | 217 | 1925-1943 | |
| 82 | Mickey Lolich | 217 | 1963-1979 | |
| 84 | Wilbur Cooper | 216 | 1912-1926 | |
| 84 | Mark Langston | 216 | 1984-1999 | |
| 86 | Stan Coveleski* | 215 | 1912-1928 | |
| 86 | Jim Perry | 215 | 1959-1975 | |
| 88 | Charlie Buffinton | 214 | 1882-1892 | |
| 89 | George Mullin | 212 | 1902-1913 | |
| 89 | Jack Quinn | 212 | 1909-1933 | |
| 91 | Bobo Newsom | 211 | 1929-1953 | |
| 91 | Billy Pierce | 211 | 1945-1964 | |
| 93 | Tom Glavine# | 210 | 1987-2001 | |
| 93 | Jesse Haines* | 210 | 1918-1937 | |
| 93 | Jamie Moyer# | 210 | 1986-2001 | |
| 93 | Jose Rijo# | 210 | 1984-2000 | |
| 97 | Vida Blue | 209 | 1969-1986 | |
| 97 | Don Drysdale* | 209 | 1956-1969 | |
| 97 | Milt Pappas | 209 | 1957-1973 | |
| 100 | Charles Bender* | 208 | 1903-1925 |
