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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Cy Young* | 316 | 1890-1911 | |
| 2 | Nolan Ryan* | 300 | 1966-1992 | |
| 3 | Pud Galvin* | 297 | 1875-1892 | |
| 4 | Walter Johnson* | 279 | 1907-1927 | |
| 5 | Phil Niekro* | 274 | 1964-1987 | |
| 6 | Gaylord Perry* | 265 | 1962-1983 | |
| 7 | Don Sutton* | 261 | 1966-1990 | |
| 8 | Jack Powell | 254 | 1897-1912 | |
| 9 | Bert Blyleven* | 253 | 1970-1990 | |
| 10 | Eppa Rixey* | 251 | 1912-1933 | |
| 11 | Bobby Mathews | 248 | 1871-1887 | |
| 12 | Robin Roberts* | 245 | 1948-1966 | |
| 12 | Warren Spahn* | 245 | 1942-1965 | |
| 14 | Steve Carlton* | 244 | 1965-1988 | |
| 14 | Early Wynn* | 244 | 1939-1963 | |
| 16 | Jim Kaat* | 237 | 1959-1983 | |
| 17 | Chick Fraser | 230 | 1894-1909 | |
| 17 | Bob Friend | 230 | 1951-1966 | |
| 17 | Ted Lyons* | 230 | 1923-1946 | |
| 17 | Rick Reuschel | 230 | 1972-1993 | |
| 21 | Jack Morris | 228 | 1977-1997 | |
| 22 | Fergie Jenkins* | 226 | 1965-1983 | |
| 23 | Red Ruffing* | 225 | 1924-1947 | |
| 24 | Tommy John* | 223 | 1963-1988 | |
| 25 | Bobo Newsom | 222 | 1929-1953 | |
| 26 | Sam Jones | 217 | 1914-1935 | |
| 27 | Gus Weyhing | 216 | 1887-1901 | |
| 28 | Tim Keefe* | 214 | 1880-1893 | |
| 29 | Red Faber* | 213 | 1914-1933 | |
| 30 | Paul Derringer | 212 | 1931-1945 | |
| 30 | Burleigh Grimes* | 212 | 1916-1934 | |
| 32 | Mickey Welch* | 210 | 1880-1892 | |
| 33 | Jerry Koosman | 209 | 1967-1985 | |
| 34 | Grover Cleveland Alexander* | 208 | 1911-1930 | |
| 34 | Kid Nichols* | 208 | 1890-1906 | |
| 34 | Joe Niekro | 208 | 1967-1988 | |
| 37 | Adonis Terry | 206 | 1884-1897 | |
| 38 | Tom Seaver* | 205 | 1967-1986 | |
| 38 | Vic Willis | 205 | 1898-1910 | |
| 40 | Frank Tanana | 204 | 1973-1990 | |
| 40 | Jim Whitney | 204 | 1881-1890 | |
| 42 | Jim McCormick | 203 | 1879-1887 | |
| 43 | Dennis Martinez | 199 | 1976-1997 | |
| 44 | Claude Osteen | 195 | 1957-1975 | |
| 44 | Frank Viola | 195 | 1982-1998 | |
| 46 | Tony Mullane | 194 | 1881-1894 | |
| 47 | Mickey Lolich | 191 | 1963-1979 | |
| 47 | Tom Zachary | 191 | 1918-1936 | |
| 49 | Jack McDowell# | 190 | 1987-2001 | |
| 49 | Bret Saberhagen | 190 | 1984-2000 | |
| 51 | Al Orth | 189 | 1895-1909 | |
| 52 | Christy Mathewson* | 188 | 1900-1916 | |
| 53 | Mel Harder | 186 | 1928-1947 | |
| 54 | Earl Whitehill | 185 | 1923-1939 | |
| 55 | Jim Bunning | 184 | 1955-1971 | |
| 55 | George Mullin | 184 | 1902-1913 | |
| 57 | Joe Bush | 183 | 1912-1928 | |
| 57 | Charlie Hough | 183 | 1970-1992 | |
| 57 | Larry Jackson | 183 | 1955-1968 | |
| 57 | Eddie Plank* | 183 | 1901-1917 | |
| 57 | Charley Radbourn* | 183 | 1880-1891 | |
| 57 | Curt Simmons | 183 | 1947-1967 | |
| 63 | Hooks Dauss | 182 | 1912-1926 | |
| 63 | Waite Hoyt* | 182 | 1918-1938 | |
| 63 | Jack Quinn | 182 | 1909-1933 | |
| 66 | Murry Dickson | 181 | 1939-1959 | |
| 66 | Dutch Leonard | 181 | 1933-1953 | |
| 66 | Rick Wise | 181 | 1964-1982 | |
| 69 | Mark Langston | 180 | 1984-1999 | |
| 69 | Lee Meadows | 180 | 1915-1929 | |
| 71 | Pink Hawley | 179 | 1892-1901 | |
| 71 | Dolf Luque | 179 | 1914-1935 | |
| 73 | Doyle Alexander | 178 | 1971-1991 | |
| 73 | John Clarkson* | 178 | 1882-1894 | |
| 73 | Wilbur Cooper | 178 | 1912-1926 | |
| 73 | Jerry Reuss | 178 | 1969-1990 | |
| 73 | Fernando Valenzuela | 178 | 1980-1999 | |
| 78 | Jimmy Key# | 177 | 1984-2001 | |
| 78 | Rube Marquard* | 177 | 1908-1925 | |
| 80 | Danny Darwin | 176 | 1978-1994 | |
| 81 | Red Donahue | 175 | 1893-1906 | |
| 81 | Tom Hughes | 175 | 1900-1913 | |
| 83 | Bob Gibson* | 174 | 1959-1975 | |
| 83 | Jim Perry | 174 | 1959-1975 | |
| 83 | Amos Rusie* | 174 | 1889-1901 | |
| 86 | Bill Dinneen | 173 | 1898-1909 | |
| 87 | Orel Hershiser | 172 | 1983-2000 | |
| 87 | Luis Tiant | 172 | 1964-1982 | |
| 89 | Larry French | 171 | 1929-1942 | |
| 90 | Ted Breitenstein | 170 | 1891-1901 | |
| 90 | Chuck Finley# | 170 | 1986-2001 | |
| 90 | Camilo Pascual | 170 | 1954-1971 | |
| 93 | Billy Pierce | 169 | 1945-1964 | |
| 94 | Greg Swindell# | 168 | 1986-2000 | |
| 95 | Red Ames | 167 | 1903-1919 | |
| 95 | Red Ehret | 167 | 1888-1898 | |
| 95 | Dwight Gooden# | 167 | 1984-2000 | |
| 98 | Don Drysdale* | 166 | 1956-1969 | |
| 98 | Dennis Eckersley | 166 | 1975-1993 | |
| 98 | Catfish Hunter* | 166 | 1965-1979 |
