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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Charley Radbourn* | 0.000 | 1884 | |
| 1 | Mike Boddicker | 0.000 | 1983 | |
| 1 | Christy Mathewson* | 0.000 | 1905 | |
| 1 | Waite Hoyt* | 0.000 | 1921 | |
| 1 | Whitey Ford* | 0.000 | 1960 | |
| 1 | Carl Hubbell* | 0.000 | 1933 | |
| 1 | Duster Mails | 0.000 | 1920 | |
| 1 | Joe McGinnity* | 0.000 | 1905 | |
| 9 | Sandy Koufax* | 0.375 | 1965 | |
| 10 | Harry Brecheen | 0.450 | 1946 | |
| 11 | Bill Hallahan | 0.491 | 1931 | |
| 12 | Mike Scott | 0.500 | 1986 | |
| 12 | Hugh Bedient | 0.500 | 1912 | |
| 12 | Spud Chandler | 0.500 | 1943 | |
| 12 | Ed Lopat | 0.500 | 1951 | |
| 12 | Rube Marquard* | 0.500 | 1912 | |
| 12 | Dick Rudolph | 0.500 | 1914 | |
| 18 | Tim Keefe* | 0.514 | 1888 | |
| 19 | Sherry Smith | 0.529 | 1920 | |
| 20 | Lon Warneke | 0.540 | 1935 | |
| 21 | Bob Welch | 0.562 | 1988 | |
| 22 | Andy Hawkins | 0.574 | 1984 | |
| 22 | Tom Hall | 0.574 | 1972 | |
| 24 | Dave Dravecky | 0.600 | 1987 | |
| 24 | Ed Walsh* | 0.600 | 1906 | |
| 26 | Dave Foutz | 0.621 | 1885 | |
| 27 | Stan Coveleski* | 0.667 | 1920 | |
| 27 | Lew Burdette | 0.667 | 1957 | |
| 29 | Blue Moon Odom | 0.711 | 1972 | |
| 30 | George Earnshaw | 0.720 | 1930 | |
| 31 | Burt Hooton | 0.818 | 1981 | |
| 32 | Ken Holtzman | 0.857 | 1974 | |
| 33 | Kirk Rueter# | 0.900 | 1998 | |
| 34 | Jack Stivetts | 0.931 | 1892 | |
| 35 | Christy Mathewson* | 0.942 | 1912 | |
| 36 | Christy Mathewson* | 0.947 | 1913 | |
| 36 | Eddie Plank* | 0.947 | 1913 | |
| 38 | Scott Williamson# | 0.964 | 1998 | |
| 39 | Steve Rogers | 0.976 | 1981 | |
| 40 | Rollie Fingers* | 0.982 | 1973 | |
| 40 | Orval Overall | 0.982 | 1908 | |
| 40 | Jack Billingham | 0.982 | 1972 | |
| 43 | Nick Altrock | 1.000 | 1906 | |
| 43 | Paul Dean | 1.000 | 1934 | |
| 43 | Kid Nichols* | 1.000 | 1892 | |
| 43 | Orval Overall | 1.000 | 1907 | |
| 43 | Carl Mays | 1.000 | 1918 | |
| 43 | Bob Gibson* | 1.000 | 1967 | |
| 43 | Hippo Vaughn | 1.000 | 1918 | |
| 43 | Johnny Podres | 1.000 | 1955 | |
| 51 | Danny Jackson | 1.038 | 1985 | |
| 51 | Charles Bender* | 1.038 | 1911 | |
| 53 | Babe Ruth* | 1.059 | 1918 | |
| 53 | Johnny Sain | 1.059 | 1948 | |
| 53 | Ron Guidry | 1.059 | 1978 | |
| 53 | Charles Bender* | 1.059 | 1905 | |
| 57 | Joe Bush | 1.080 | 1923 | |
| 57 | Jesse Haines* | 1.080 | 1926 | |
| 59 | Ben McDonald# | 1.102 | 1992 | |
| 60 | Mort Cooper | 1.125 | 1944 | |
| 60 | Whitey Ford* | 1.125 | 1957 | |
| 60 | Cliff Politte# | 1.125 | 2000 | |
| 60 | Pedro Martinez# | 1.125 | 1992 | |
| 60 | John Clarkson* | 1.125 | 1885 | |
| 65 | Scott McGregor | 1.141 | 1983 | |
| 66 | Don Gullett | 1.174 | 1976 | |
| 66 | Matt Morris# | 1.174 | 2000 | |
| 66 | Lefty Tyler | 1.174 | 1918 | |
| 69 | Orel Hershiser | 1.200 | 1988 | |
| 69 | Waite Hoyt* | 1.200 | 1926 | |
| 69 | Mark Gubicza | 1.200 | 1991 | |
| 72 | Herb Pennock* | 1.227 | 1926 | |
| 72 | Joe Magrane | 1.227 | 1989 | |
| 74 | Rick Aguilera | 1.241 | 1988 | |
| 75 | Grover Cleveland Alexander* | 1.328 | 1926 | |
| 75 | Steve Carlton* | 1.328 | 1983 | |
| 77 | Babe Adams | 1.333 | 1909 | |
| 78 | Ben McDonald# | 1.350 | 1998 | |
| 78 | Jack Coombs | 1.350 | 1911 | |
| 78 | Red Ehret | 1.350 | 1890 | |
| 81 | Bobo Newsom | 1.385 | 1940 | |
| 81 | Art Nehf | 1.385 | 1921 | |
| 83 | Jon Matlack | 1.403 | 1973 | |
| 84 | Bert Blyleven* | 1.421 | 1979 | |
| 84 | Dickey Kerr | 1.421 | 1919 | |
| 84 | Mickey Lolich | 1.421 | 1972 | |
| 84 | Lefty Grove* | 1.421 | 1930 | |
| 88 | Lefty Gomez* | 1.500 | 1937 | |
| 88 | Don Sutton* | 1.500 | 1974 | |
| 88 | Denny Galehouse | 1.500 | 1944 | |
| 88 | Lady Baldwin | 1.500 | 1887 | |
| 88 | Bucky Walters | 1.500 | 1940 | |
| 88 | Sandy Koufax* | 1.500 | 1963 | |
| 88 | Red Ruffing* | 1.500 | 1938 | |
| 88 | Waite Hoyt* | 1.500 | 1928 | |
| 88 | Mike Cuellar | 1.500 | 1969 | |
| 97 | Ernie Shore | 1.528 | 1916 | |
| 97 | Grover Cleveland Alexander* | 1.528 | 1915 | |
| 99 | Jim Bouton | 1.558 | 1964 | |
| 100 | Pedro Martinez# | 1.562 | 1996 |
