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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | H9 | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Pedro Martinez# | 2.25 | 1992 | |
| 2 | Andy Hawkins | 2.30 | 1984 | |
| 3 | Bob Welch | 3.38 | 1988 | |
| 4 | Orval Overall | 3.44 | 1908 | |
| 5 | Duster Mails | 3.45 | 1920 | |
| 6 | Blue Moon Odom | 3.55 | 1972 | |
| 7 | Nolan Ryan* | 3.60 | 1981 | |
| 8 | Joe Bush | 3.78 | 1923 | |
| 8 | Claude Passeau | 3.78 | 1945 | |
| 10 | Matt Morris# | 3.91 | 2000 | |
| 11 | Mike Boddicker | 4.00 | 1983 | |
| 11 | Bucky Walters | 4.00 | 1940 | |
| 11 | Mike Scott | 4.00 | 1986 | |
| 14 | Don Gullett | 4.11 | 1976 | |
| 15 | Dave Dravecky | 4.20 | 1987 | |
| 15 | Ed Walsh* | 4.20 | 1906 | |
| 17 | Jon Matlack | 4.21 | 1973 | |
| 18 | Eddie Plank* | 4.26 | 1913 | |
| 19 | Randy Johnson# | 4.32 | 1995 | |
| 20 | Christy Mathewson* | 4.33 | 1905 | |
| 21 | Art Nehf | 4.50 | 1921 | |
| 21 | Greg Maddux# | 4.50 | 1990 | |
| 21 | Charley Radbourn* | 4.50 | 1884 | |
| 21 | Kirk Rueter# | 4.50 | 1998 | |
| 21 | Kirk Rueter# | 4.50 | 1999 | |
| 21 | George Earnshaw | 4.50 | 1931 | |
| 27 | Burleigh Grimes* | 4.58 | 1931 | |
| 28 | Rollie Fingers* | 4.60 | 1972 | |
| 29 | Tim Keefe* | 4.63 | 1888 | |
| 30 | Dave McNally | 4.67 | 1969 | |
| 30 | Bob Gibson* | 4.67 | 1967 | |
| 32 | George Earnshaw | 4.68 | 1930 | |
| 33 | Charles Bender* | 4.76 | 1905 | |
| 33 | Vida Blue | 4.76 | 1974 | |
| 33 | Johnny Sain | 4.76 | 1948 | |
| 36 | Don Sutton* | 4.80 | 1974 | |
| 36 | Billy Pierce | 4.80 | 1962 | |
| 38 | Scott Williamson# | 4.82 | 1998 | |
| 39 | Lon Warneke | 4.86 | 1935 | |
| 40 | Dave Stieb | 4.87 | 1985 | |
| 41 | Sandy Koufax* | 4.88 | 1965 | |
| 42 | Jack Coombs | 4.95 | 1911 | |
| 43 | Stan Coveleski* | 5.00 | 1920 | |
| 43 | Ed Lopat | 5.00 | 1951 | |
| 43 | Hugh Bedient | 5.00 | 1912 | |
| 43 | Carl Mays | 5.00 | 1918 | |
| 47 | Mort Cooper | 5.06 | 1944 | |
| 47 | Ross Grimsley | 5.06 | 1972 | |
| 49 | Tom Hall | 5.17 | 1972 | |
| 50 | Jim Lonborg | 5.25 | 1967 | |
| 51 | Rick Aguilera | 5.28 | 1988 | |
| 51 | Paul Derringer | 5.28 | 1939 | |
| 53 | Burleigh Grimes* | 5.29 | 1930 | |
| 53 | Joe McGinnity* | 5.29 | 1905 | |
| 53 | Sherry Smith | 5.29 | 1920 | |
| 53 | Mickey Welch* | 5.29 | 1888 | |
| 57 | Charlie Hough | 5.30 | 1989 | |
| 58 | Allie Reynolds | 5.31 | 1952 | |
| 58 | Grover Cleveland Alexander* | 5.31 | 1926 | |
| 60 | Herb Pennock* | 5.32 | 1926 | |
| 61 | Charlie Hough | 5.40 | 1988 | |
| 61 | Red Ehret | 5.40 | 1890 | |
| 61 | Jim Konstanty | 5.40 | 1950 | |
| 61 | Jack Billingham | 5.40 | 1972 | |
| 61 | Mark Gubicza | 5.40 | 1991 | |
| 66 | Lefty Tyler | 5.48 | 1918 | |
| 67 | Whitey Ford* | 5.50 | 1960 | |
| 67 | Nick Altrock | 5.50 | 1906 | |
| 69 | Jesse Barnes | 5.51 | 1921 | |
| 69 | Art Nehf | 5.51 | 1923 | |
| 69 | Bob Turley | 5.51 | 1958 | |
| 69 | Mike Norris | 5.51 | 1981 | |
| 73 | Charles Bender* | 5.54 | 1911 | |
| 74 | Jerry Koosman | 5.64 | 1969 | |
| 75 | Hippo Vaughn | 5.67 | 1918 | |
| 76 | Scott McGregor | 5.70 | 1983 | |
| 77 | Ron Guidry | 5.75 | 1977 | |
| 78 | Tug McGraw | 5.79 | 1973 | |
| 79 | Carl Hubbell* | 5.85 | 1933 | |
| 80 | Spec Shea | 5.87 | 1947 | |
| 81 | Bill Hallahan | 5.89 | 1931 | |
| 82 | Gary Nolan | 5.94 | 1972 | |
| 83 | Warren Spahn* | 5.97 | 1958 | |
| 84 | Rube Foster | 6.00 | 1915 | |
| 84 | Mike Cuellar | 6.00 | 1969 | |
| 84 | Lady Baldwin | 6.00 | 1887 | |
| 84 | Burt Hooton | 6.00 | 1981 | |
| 84 | Carl Erskine | 6.00 | 1952 | |
| 84 | Sandy Koufax* | 6.00 | 1963 | |
| 84 | Tim Keefe* | 6.00 | 1884 | |
| 84 | Babe Adams | 6.00 | 1909 | |
| 84 | Waite Hoyt* | 6.00 | 1921 | |
| 84 | Darryl Kile# | 6.00 | 1992 | |
| 84 | Roy Halladay# | 6.00 | 2000 | |
| 84 | Dick Rudolph | 6.00 | 1914 | |
| 84 | Dick Ruthven | 6.00 | 1980 | |
| 84 | Bob Gibson* | 6.00 | 1968 | |
| 98 | Alex Fernandez# | 6.04 | 1999 | |
| 98 | Mark Langston | 6.04 | 1990 | |
| 100 | Ernie Shore | 6.11 | 1916 |
