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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Kenny Rogers# | 192.0 | 1989-2001 | |
| 2 | Bob Caruthers | 147.0 | 1884-1893 | |
| 3 | Randy Johnson# | 146.0 | 1988-2001 | |
| 3 | Whitey Ford* | 146.0 | 1950-1967 | |
| 5 | Pedro Martinez# | 144.0 | 1991-2001 | |
| 6 | Roger Clemens# | 135.0 | 1984-2001 | |
| 7 | Catfish Hunter* | 132.0 | 1965-1979 | |
| 8 | Jose Rijo# | 128.0 | 1984-2000 | |
| 9 | Jim Palmer* | 124.0 | 1965-1984 | |
| 10 | Fernando Valenzuela | 123.0 | 1980-1999 | |
| 11 | Aaron Sele# | 122.0 | 1991-2001 | |
| 12 | Kevin Brown# | 114.0 | 1986-2001 | |
| 13 | Tom Glavine# | 104.0 | 1987-2001 | |
| 14 | Christy Mathewson* | 101.0 | 1900-1916 | |
| 14 | David Cone# | 101.0 | 1986-2001 | |
| 14 | Don Sutton* | 101.0 | 1966-1990 | |
| 17 | Steve Carlton* | 99.0 | 1965-1988 | |
| 18 | Don Gullett | 93.0 | 1970-1978 | |
| 19 | Tommy John* | 92.0 | 1963-1988 | |
| 19 | Mark Langston | 92.0 | 1984-1999 | |
| 21 | Al Leiter# | 90.0 | 1987-2001 | |
| 21 | Dave McNally | 90.0 | 1962-1975 | |
| 23 | David Wells# | 88.0 | 1987-2001 | |
| 24 | Jim Abbott# | 86.0 | 1989-2001 | |
| 25 | Red Ruffing* | 85.0 | 1924-1947 | |
| 25 | Mike Cuellar | 85.0 | 1959-1977 | |
| 25 | Charles Bender* | 85.0 | 1903-1925 | |
| 28 | Steve Avery# | 83.0 | 1989-2001 | |
| 28 | Waite Hoyt* | 83.0 | 1918-1938 | |
| 28 | Ben McDonald# | 83.0 | 1989-2001 | |
| 31 | Bob Gibson* | 81.0 | 1959-1975 | |
| 32 | Art Nehf | 79.0 | 1915-1929 | |
| 32 | Dave Stewart | 79.0 | 1978-1999 | |
| 34 | Doug Drabek# | 78.0 | 1986-2000 | |
| 35 | Allie Reynolds | 77.0 | 1942-1954 | |
| 36 | Alex Fernandez# | 75.0 | 1990-2001 | |
| 36 | Dave Foutz | 75.0 | 1884-1896 | |
| 38 | Wilson Alvarez# | 74.0 | 1990-2001 | |
| 38 | Sid Fernandez | 74.0 | 1983-1999 | |
| 40 | John Smoltz# | 72.0 | 1988-2001 | |
| 40 | Chris Carpenter# | 72.0 | 1995-2001 | |
| 42 | Charlie Hough | 70.0 | 1970-1992 | |
| 42 | Ken Holtzman | 70.0 | 1965-1979 | |
| 42 | Orel Hershiser | 70.0 | 1983-2000 | |
| 45 | Chris Haney# | 69.0 | 1991-2001 | |
| 45 | Mike Jeffcoat | 69.0 | 1983-1999 | |
| 45 | Darryl Kile# | 69.0 | 1989-2001 | |
| 48 | Bob Welch | 68.0 | 1978-1994 | |
| 49 | James Baldwin# | 66.0 | 1992-2001 | |
| 49 | Curt Schilling# | 66.0 | 1988-2001 | |
| 49 | Silver King | 66.0 | 1886-1897 | |
| 52 | Vida Blue | 64.0 | 1969-1986 | |
| 52 | Ron Guidry | 64.0 | 1975-1990 | |
| 52 | John Clarkson* | 64.0 | 1882-1894 | |
| 55 | Jose Lima# | 63.0 | 1993-2001 | |
| 56 | George Earnshaw | 62.0 | 1928-1936 | |
| 56 | Jerry Reuss | 62.0 | 1969-1990 | |
| 56 | Adonis Terry | 62.0 | 1884-1897 | |
| 59 | Tom Seaver* | 61.0 | 1967-1986 | |
| 59 | Tim Keefe* | 61.0 | 1880-1893 | |
| 59 | Darren Oliver# | 61.0 | 1990-2001 | |
| 59 | Kirk Rueter# | 61.0 | 1992-2001 | |
| 59 | Nolan Ryan* | 61.0 | 1966-1992 | |
| 59 | Cy Young* | 61.0 | 1890-1911 | |
| 65 | Joe Bush | 60.0 | 1912-1928 | |
| 65 | Vic Raschi | 60.0 | 1946-1955 | |
| 65 | John Candelaria | 60.0 | 1975-1991 | |
| 68 | Burt Hooton | 59.0 | 1971-1985 | |
| 68 | Andy Pettitte# | 59.0 | 1992-2001 | |
| 68 | Gary Nolan | 59.0 | 1967-1977 | |
| 68 | Bob Ojeda | 59.0 | 1980-1998 | |
| 68 | Carl Pavano# | 59.0 | 1995-2001 | |
| 73 | Rube Marquard* | 58.0 | 1908-1925 | |
| 73 | Charlie Getzein | 58.0 | 1884-1892 | |
| 73 | Mike Morgan | 58.0 | 1978-1999 | |
| 73 | George Mullin | 58.0 | 1902-1913 | |
| 77 | Mordecai Brown* | 57.0 | 1903-1916 | |
| 77 | Rollie Fingers* | 57.0 | 1968-1985 | |
| 77 | Carl Mays | 57.0 | 1915-1929 | |
| 77 | Sandy Koufax* | 57.0 | 1955-1966 | |
| 77 | John Tudor | 57.0 | 1979-1996 | |
| 82 | Burleigh Grimes* | 56.0 | 1916-1934 | |
| 82 | Warren Spahn* | 56.0 | 1942-1965 | |
| 84 | Joe Magrane | 55.0 | 1987-1999 | |
| 84 | Jeff Suppan# | 55.0 | 1995-2001 | |
| 84 | Herb Pennock* | 55.0 | 1912-1934 | |
| 84 | Ed Crane | 55.0 | 1885-1893 | |
| 88 | Eddie Plank* | 54.0 | 1901-1917 | |
| 89 | Bob Turley | 53.0 | 1951-1963 | |
| 89 | Jack Coombs | 53.0 | 1906-1920 | |
| 91 | Paul Derringer | 52.0 | 1931-1945 | |
| 91 | Greg Maddux# | 52.0 | 1986-2001 | |
| 91 | Tug McGraw | 52.0 | 1965-1984 | |
| 91 | Frank Viola | 52.0 | 1982-1998 | |
| 91 | Ed Lopat | 52.0 | 1944-1955 | |
| 96 | Danny Cox | 51.0 | 1983-1994 | |
| 96 | Lefty Grove* | 51.0 | 1925-1941 | |
| 96 | Terry Mulholland# | 51.0 | 1986-2001 | |
| 96 | Orval Overall | 51.0 | 1905-1913 | |
| 96 | Dave Righetti | 51.0 | 1979-1996 |
