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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Matt Kilroy | 513 | 1886 | |
| 2 | Toad Ramsey | 499 | 1886 | |
| 3 | Charley Radbourn* | 441 | 1884 | |
| 4 | Charlie Buffinton | 417 | 1884 | |
| 5 | Pedro Martinez# | 401 | 1992 | |
| 6 | Guy Hecker | 385 | 1884 | |
| 7 | Nolan Ryan* | 383 | 1973 | |
| 8 | Sandy Koufax* | 382 | 1965 | |
| 9 | Pedro Martinez# | 377 | 1993 | |
| 10 | Pud Galvin* | 369 | 1884 | |
| 11 | Mark Baldwin | 368 | 1889 | |
| 12 | Nolan Ryan* | 367 | 1974 | |
| 13 | Tim Keefe* | 361 | 1883 | |
| 14 | Toad Ramsey | 355 | 1887 | |
| 15 | Rube Waddell* | 349 | 1904 | |
| 16 | Bob Feller* | 348 | 1946 | |
| 17 | Hardie Henderson | 346 | 1884 | |
| 18 | Mickey Welch* | 345 | 1884 | |
| 18 | Jim Whitney | 345 | 1883 | |
| 20 | Nolan Ryan* | 341 | 1977 | |
| 20 | Amos Rusie* | 341 | 1890 | |
| 22 | Amos Rusie* | 337 | 1891 | |
| 23 | Tim Keefe* | 335 | 1888 | |
| 24 | Tim Keefe* | 334 | 1884 | |
| 25 | Nolan Ryan* | 329 | 1972 | |
| 26 | Nolan Ryan* | 327 | 1976 | |
| 27 | Ed Morris | 326 | 1886 | |
| 28 | Sam McDowell | 325 | 1965 | |
| 29 | Lady Baldwin | 323 | 1886 | |
| 30 | Pedro Martinez# | 321 | 1998 | |
| 31 | Randy Johnson# | 318 | 1998 | |
| 32 | Sandy Koufax* | 317 | 1966 | |
| 32 | Pedro Martinez# | 317 | 1994 | |
| 34 | Randy Johnson# | 315 | 1994 | |
| 34 | Charley Radbourn* | 315 | 1883 | |
| 36 | Bill Hutchison | 314 | 1892 | |
| 37 | Walter Johnson* | 313 | 1910 | |
| 37 | J.R. Richard | 313 | 1979 | |
| 37 | John Clarkson* | 313 | 1886 | |
| 40 | Steve Carlton* | 310 | 1972 | |
| 41 | John Clarkson* | 308 | 1885 | |
| 41 | Mickey Lolich | 308 | 1971 | |
| 43 | Sandy Koufax* | 306 | 1963 | |
| 43 | Mike Scott | 306 | 1986 | |
| 45 | Sam McDowell | 304 | 1970 | |
| 46 | Walter Johnson* | 303 | 1912 | |
| 46 | J.R. Richard | 303 | 1978 | |
| 48 | Rube Waddell* | 302 | 1903 | |
| 48 | Ed Morris | 302 | 1884 | |
| 50 | Vida Blue | 301 | 1971 | |
| 51 | Randy Johnson# | 300 | 1996 | |
| 52 | Ed Morris | 298 | 1885 | |
| 53 | Tim Keefe* | 297 | 1886 | |
| 54 | Randy Johnson# | 293 | 1988 | |
| 55 | Jack Lynch | 292 | 1884 | |
| 56 | Sadie McMahon | 291 | 1890 | |
| 57 | Bill Hutchison | 289 | 1890 | |
| 57 | Jack Stivetts | 289 | 1890 | |
| 57 | Tom Seaver* | 289 | 1971 | |
| 60 | Amos Rusie* | 288 | 1892 | |
| 60 | Roy Halladay# | 288 | 2000 | |
| 62 | Rube Waddell* | 287 | 1905 | |
| 63 | Steve Carlton* | 286 | 1980 | |
| 63 | Steve Carlton* | 286 | 1982 | |
| 63 | Bobby Mathews | 286 | 1885 | |
| 63 | Bobby Mathews | 286 | 1884 | |
| 67 | John Clarkson* | 284 | 1889 | |
| 68 | Sam McDowell | 283 | 1968 | |
| 68 | Dave Foutz | 283 | 1886 | |
| 68 | Tom Seaver* | 283 | 1970 | |
| 71 | Randy Johnson# | 282 | 1995 | |
| 72 | Denny McLain | 280 | 1968 | |
| 73 | Sam McDowell | 279 | 1969 | |
| 73 | Pud Galvin* | 279 | 1883 | |
| 73 | Roy Halladay# | 279 | 1999 | |
| 76 | Pedro Martinez# | 278 | 1997 | |
| 77 | Dwight Gooden# | 276 | 1984 | |
| 77 | Bob Veale | 276 | 1965 | |
| 79 | Steve Carlton* | 275 | 1983 | |
| 79 | Hal Newhouser | 275 | 1946 | |
| 81 | Bob Gibson* | 274 | 1970 | |
| 81 | Mario Soto | 274 | 1982 | |
| 81 | Fergie Jenkins* | 274 | 1970 | |
| 84 | Fergie Jenkins* | 273 | 1969 | |
| 85 | Mickey Welch* | 272 | 1886 | |
| 85 | Pedro Martinez# | 272 | 2000 | |
| 85 | Ed Seward | 272 | 1888 | |
| 85 | Larry Corcoran | 272 | 1884 | |
| 89 | Mickey Lolich | 271 | 1969 | |
| 90 | Jim Whitney | 270 | 1884 | |
| 90 | Nolan Ryan* | 270 | 1987 | |
| 90 | Bob Gibson* | 270 | 1965 | |
| 93 | Ed Walsh* | 269 | 1908 | |
| 93 | Sandy Koufax* | 269 | 1961 | |
| 93 | Frank Tanana | 269 | 1975 | |
| 93 | Bob Gibson* | 269 | 1969 | |
| 97 | Bob Gibson* | 268 | 1968 | |
| 97 | Dwight Gooden# | 268 | 1985 | |
| 97 | Larry Corcoran | 268 | 1880 | |
| 97 | Jim Bunning | 268 | 1965 |
