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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Pedro Martinez# | 13.92 | 1993 | |
| 2 | Pedro Martinez# | 12.26 | 1992 | |
| 3 | Nolan Ryan* | 11.48 | 1987 | |
| 4 | Dwight Gooden# | 11.39 | 1984 | |
| 5 | Randy Johnson# | 11.00 | 1994 | |
| 6 | Kerry Wood# | 10.95 | 2000 | |
| 7 | Pedro Martinez# | 10.93 | 1998 | |
| 8 | Pedro Martinez# | 10.89 | 1994 | |
| 9 | Sam McDowell | 10.71 | 1965 | |
| 10 | Randy Johnson# | 10.65 | 1988 | |
| 11 | Nolan Ryan* | 10.57 | 1973 | |
| 12 | Sandy Koufax* | 10.55 | 1962 | |
| 13 | Roy Halladay# | 10.45 | 2000 | |
| 14 | Kerry Wood# | 10.43 | 1999 | |
| 14 | Nolan Ryan* | 10.43 | 1972 | |
| 16 | Sam McDowell | 10.42 | 1966 | |
| 17 | Nolan Ryan* | 10.35 | 1976 | |
| 18 | Randy Johnson# | 10.29 | 1998 | |
| 19 | Nolan Ryan* | 10.26 | 1977 | |
| 20 | Sandy Koufax* | 10.24 | 1965 | |
| 21 | Randy Wolf# | 10.15 | 1999 | |
| 22 | Sandy Koufax* | 10.13 | 1960 | |
| 23 | Randy Johnson# | 10.06 | 1996 | |
| 24 | Mike Scott | 10.00 | 1986 | |
| 25 | Pedro Martinez# | 9.99 | 2000 | |
| 26 | Nolan Ryan* | 9.97 | 1978 | |
| 27 | Nolan Ryan* | 9.93 | 1974 | |
| 28 | J.R. Richard | 9.90 | 1978 | |
| 29 | Nolan Ryan* | 9.81 | 1986 | |
| 30 | Randy Wolf# | 9.78 | 2000 | |
| 31 | Matt Clement# | 9.76 | 1998 | |
| 31 | Roy Halladay# | 9.76 | 1999 | |
| 33 | Herb Score | 9.70 | 1955 | |
| 33 | Randy Johnson# | 9.70 | 1995 | |
| 35 | Nolan Ryan* | 9.65 | 1984 | |
| 35 | Pedro Martinez# | 9.65 | 1997 | |
| 37 | J.R. Richard | 9.64 | 1979 | |
| 38 | Mario Soto | 9.57 | 1982 | |
| 39 | Tom Griffin | 9.56 | 1969 | |
| 40 | Rick Ankiel# | 9.55 | 2000 | |
| 40 | Chan-ho Park# | 9.55 | 1996 | |
| 42 | Jim Maloney | 9.53 | 1963 | |
| 43 | Sid Fernandez | 9.51 | 1985 | |
| 44 | Jason Schmidt# | 9.49 | 1997 | |
| 44 | Herb Score | 9.49 | 1956 | |
| 46 | Sandy Koufax* | 9.47 | 1961 | |
| 46 | Sam McDowell | 9.47 | 1968 | |
| 48 | Randy Johnson# | 9.45 | 1993 | |
| 49 | Frank Tanana | 9.41 | 1975 | |
| 50 | Roy Halladay# | 9.40 | 1998 | |
| 50 | Don Wilson | 9.40 | 1969 | |
| 52 | Jason Schmidt# | 9.34 | 1999 | |
| 52 | Bob Veale | 9.34 | 1965 | |
| 54 | Al Leiter# | 9.32 | 1994 | |
| 55 | Randy Johnson# | 9.28 | 1997 | |
| 56 | Luis Tiant | 9.22 | 1967 | |
| 57 | Mark Langston | 9.21 | 1986 | |
| 57 | Matt Clement# | 9.21 | 1997 | |
| 59 | John Smoltz# | 9.20 | 1998 | |
| 59 | Luis Tiant | 9.20 | 1968 | |
| 61 | Dave Boswell | 9.19 | 1966 | |
| 61 | Sam McDowell | 9.19 | 1964 | |
| 63 | Al Leiter# | 9.17 | 1990 | |
| 64 | Sonny Siebert | 9.11 | 1965 | |
| 64 | Aaron Sele# | 9.11 | 1994 | |
| 66 | Randy Johnson# | 9.09 | 1989 | |
| 67 | Tom Seaver* | 9.08 | 1971 | |
| 68 | Dennis Eckersley | 9.03 | 1976 | |
| 69 | Nolan Ryan* | 9.01 | 1979 | |
| 70 | Sandy Koufax* | 9.00 | 1964 | |
| 71 | Sam McDowell | 8.99 | 1967 | |
| 72 | Sam McDowell | 8.97 | 1970 | |
| 73 | Randy Wolf# | 8.93 | 1998 | |
| 74 | Jim Maloney | 8.92 | 1964 | |
| 75 | Rick Ankiel# | 8.91 | 1999 | |
| 76 | Aaron Sele# | 8.86 | 1995 | |
| 76 | Sandy Koufax* | 8.86 | 1963 | |
| 78 | Sandy Koufax* | 8.83 | 1966 | |
| 79 | Sam McDowell | 8.81 | 1969 | |
| 79 | Sid Fernandez | 8.81 | 1986 | |
| 79 | Nolan Ryan* | 8.81 | 1982 | |
| 82 | Tony Saunders# | 8.80 | 1999 | |
| 83 | Tom Seaver* | 8.76 | 1970 | |
| 83 | Al Downing | 8.76 | 1963 | |
| 85 | Bob Moose | 8.74 | 1969 | |
| 86 | Steve Carlton* | 8.73 | 1983 | |
| 87 | Dwight Gooden# | 8.72 | 1985 | |
| 88 | Steve Carlton* | 8.71 | 1982 | |
| 89 | Pedro Martinez# | 8.70 | 1995 | |
| 90 | Juan Pizarro | 8.69 | 1961 | |
| 90 | Mickey Lolich | 8.69 | 1969 | |
| 92 | Vida Blue | 8.68 | 1971 | |
| 93 | Mark Langston | 8.67 | 1987 | |
| 94 | Bob Johnson | 8.66 | 1970 | |
| 95 | Jim Maloney | 8.65 | 1966 | |
| 96 | Bruce Hurst | 8.62 | 1986 | |
| 97 | Mario Soto | 8.61 | 1980 | |
| 98 | Jim Maloney | 8.60 | 1965 | |
| 99 | Roy Oswalt# | 8.56 | 1999 | |
| 100 | Tom Seaver* | 8.55 | 1972 |
