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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Hank Aaron* | 755 | 1954-1976 | |
| 2 | Babe Ruth* | 714 | 1914-1935 | |
| 3 | Willie Mays* | 660 | 1951-1973 | |
| 4 | Eddie Murray | 623 | 1977-1999 | |
| 5 | Mark McGwire# | 615 | 1986-2001 | |
| 6 | Frank Robinson* | 586 | 1956-1976 | |
| 7 | Harmon Killebrew* | 573 | 1954-1975 | |
| 8 | Reggie Jackson* | 563 | 1967-1987 | |
| 9 | Mike Schmidt* | 561 | 1972-1991 | |
| 10 | Barry Bonds# | 558 | 1986-2001 | |
| 11 | Jose Canseco# | 545 | 1985-2000 | |
| 12 | Mickey Mantle* | 536 | 1951-1968 | |
| 13 | Jimmie Foxx* | 534 | 1925-1945 | |
| 14 | Willie McCovey* | 521 | 1959-1980 | |
| 14 | Ted Williams* | 521 | 1939-1960 | |
| 16 | Ernie Banks* | 512 | 1953-1971 | |
| 16 | Eddie Mathews* | 512 | 1952-1968 | |
| 18 | Mel Ott* | 511 | 1926-1947 | |
| 19 | Ken Griffey Jr.# | 502 | 1988-2001 | |
| 20 | Lou Gehrig* | 493 | 1923-1939 | |
| 21 | Sammy Sosa# | 487 | 1990-2001 | |
| 22 | Stan Musial* | 475 | 1941-1963 | |
| 22 | Willie Stargell* | 475 | 1962-1982 | |
| 24 | Jim Rice* | 471 | 1974-1994 | |
| 25 | David Justice# | 458 | 1988-2001 | |
| 25 | Rafael Palmeiro# | 458 | 1986-2001 | |
| 27 | Carl Yastrzemski* | 452 | 1961-1983 | |
| 28 | Bo Jackson# | 446 | 1986-2001 | |
| 29 | Gary Sheffield# | 445 | 1988-2001 | |
| 30 | Dave Kingman | 442 | 1971-1986 | |
| 31 | Fred McGriff# | 432 | 1986-2001 | |
| 32 | Darryl Strawberry | 426 | 1983-2000 | |
| 32 | Billy Williams* | 426 | 1959-1976 | |
| 34 | Will Clark# | 415 | 1986-2000 | |
| 35 | Harold Baines | 414 | 1980-1999 | |
| 36 | Darrell Evans | 408 | 1969-1989 | |
| 36 | Dale Murphy* | 408 | 1976-1992 | |
| 36 | Frank Thomas# | 408 | 1989-2001 | |
| 39 | Duke Snider* | 407 | 1947-1964 | |
| 40 | Albert Belle# | 403 | 1988-2001 | |
| 41 | Dave Winfield | 402 | 1973-1992 | |
| 42 | Al Kaline* | 399 | 1953-1974 | |
| 42 | Matt Williams# | 399 | 1987-2000 | |
| 44 | Andres Galarraga# | 398 | 1985-2000 | |
| 45 | Graig Nettles | 392 | 1967-1988 | |
| 46 | Jeff Bagwell# | 390 | 1989-2001 | |
| 47 | Johnny Bench* | 389 | 1967-1983 | |
| 48 | Jesse Barfield | 388 | 1981-1998 | |
| 49 | Cal Ripken Jr. | 386 | 1981-2000 | |
| 50 | Frank Howard | 382 | 1958-1973 | |
| 51 | Orlando Cepeda | 379 | 1958-1974 | |
| 51 | Tony Perez | 379 | 1964-1986 | |
| 53 | Norm Cash | 377 | 1958-1974 | |
| 54 | Rocky Colavito | 374 | 1955-1968 | |
| 55 | John Jaha# | 372 | 1989-2000 | |
| 56 | Eric Davis# | 370 | 1984-2000 | |
| 56 | Dwight Evans | 370 | 1972-1992 | |
| 56 | Gil Hodges | 370 | 1943-1963 | |
| 59 | Ralph Kiner* | 369 | 1946-1955 | |
| 60 | Ryne Sandberg | 368 | 1981-2000 | |
| 61 | Carlton Fisk* | 365 | 1969-1991 | |
| 62 | Joe DiMaggio* | 361 | 1936-1951 | |
| 63 | Johnny Mize* | 359 | 1936-1953 | |
| 64 | Yogi Berra* | 358 | 1946-1965 | |
| 65 | Lee May | 354 | 1965-1982 | |
| 66 | Dick Allen | 351 | 1963-1977 | |
| 66 | Don Mattingly# | 351 | 1982-2001 | |
| 66 | Danny Tartabull | 351 | 1984-1999 | |
| 69 | Larry Walker# | 350 | 1989-2001 | |
| 70 | Luis Gonzalez# | 349 | 1989-2001 | |
| 71 | George Foster | 348 | 1969-1986 | |
| 72 | Mo Vaughn# | 343 | 1989-2000 | |
| 73 | Ron Santo | 342 | 1960-1974 | |
| 74 | Gary Carter* | 341 | 1974-1992 | |
| 75 | Boog Powell | 339 | 1961-1977 | |
| 76 | Don Baylor | 337 | 1970-1989 | |
| 77 | Joe Adcock | 336 | 1950-1966 | |
| 78 | Kevin Mitchell | 335 | 1984-2000 | |
| 79 | Bobby Bonds | 332 | 1968-1981 | |
| 80 | Hank Greenberg* | 331 | 1930-1947 | |
| 81 | Willie Horton | 325 | 1963-1980 | |
| 82 | George Brett* | 321 | 1973-1995 | |
| 83 | Kent Hrbek | 318 | 1981-1996 | |
| 83 | Roy Sievers | 318 | 1949-1965 | |
| 85 | Ron Cey | 316 | 1971-1987 | |
| 86 | Gary Gaetti | 315 | 1981-1995 | |
| 87 | Andre Dawson | 314 | 1976-1991 | |
| 87 | Reggie Smith | 314 | 1966-1982 | |
| 89 | Tom Brunansky | 307 | 1981-1996 | |
| 89 | Greg Luzinski | 307 | 1970-1984 | |
| 89 | Al Simmons* | 307 | 1924-1944 | |
| 92 | Cecil Fielder | 303 | 1985-1997 | |
| 92 | Alex Rodriguez# | 303 | 1994-2001 | |
| 94 | George Bell | 302 | 1981-1995 | |
| 94 | Javy Lopez# | 302 | 1990-2001 | |
| 96 | Rogers Hornsby* | 301 | 1915-1937 | |
| 97 | Ellis Burks# | 300 | 1987-2000 | |
| 97 | Chuck Klein* | 300 | 1928-1944 | |
| 97 | Fred Lynn | 300 | 1974-1990 | |
| 100 | Jim Edmonds# | 299 | 1989-2001 |
