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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | R | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jim Thome# | 185 | 1999 | |
| 2 | Mark McGwire# | 174 | 1994 | |
| 3 | Jason Giambi# | 173 | 1999 | |
| 4 | Lou Gehrig* | 167 | 1936 | |
| 5 | Jason Giambi# | 166 | 2000 | |
| 6 | Lou Gehrig* | 163 | 1931 | |
| 6 | Jim Thome# | 163 | 2000 | |
| 8 | Cliff Floyd# | 161 | 1995 | |
| 9 | Chipper Jones# | 159 | 1999 | |
| 10 | Cliff Floyd# | 153 | 1997 | |
| 10 | Dan Brouthers* | 153 | 1887 | |
| 12 | Frank Thomas# | 151 | 1994 | |
| 12 | Jimmie Foxx* | 151 | 1932 | |
| 14 | Jeff Bagwell# | 150 | 1998 | |
| 14 | Edgar Martinez# | 150 | 1996 | |
| 16 | Todd Helton# | 149 | 1999 | |
| 16 | Lou Gehrig* | 149 | 1927 | |
| 18 | Carlos Delgado# | 148 | 1996 | |
| 19 | Tony Gwynn | 147 | 1994 | |
| 19 | Jeff Bagwell# | 147 | 1999 | |
| 21 | Jermaine Dye# | 145 | 2000 | |
| 22 | Hank Greenberg* | 144 | 1938 | |
| 23 | Lou Gehrig* | 143 | 1930 | |
| 24 | Jose Canseco# | 140 | 1989 | |
| 25 | Bill Terry* | 139 | 1930 | |
| 25 | Jimmie Foxx* | 139 | 1938 | |
| 25 | Dan Brouthers* | 139 | 1886 | |
| 25 | Derrek Lee# | 139 | 2000 | |
| 25 | Charlie Comiskey* | 139 | 1887 | |
| 25 | Lou Gehrig* | 139 | 1928 | |
| 31 | Lou Gehrig* | 138 | 1933 | |
| 31 | Lou Gehrig* | 138 | 1937 | |
| 31 | Cliff Floyd# | 138 | 1996 | |
| 31 | Lou Gehrig* | 138 | 1932 | |
| 35 | Johnny Mize* | 137 | 1947 | |
| 35 | Dan Brouthers* | 137 | 1894 | |
| 35 | George Sisler* | 137 | 1920 | |
| 35 | Edgar Martinez# | 137 | 1995 | |
| 35 | Mark McGwire# | 137 | 1996 | |
| 35 | Hank Greenberg* | 137 | 1937 | |
| 41 | Lou Gehrig* | 135 | 1926 | |
| 41 | Rafael Palmeiro# | 135 | 1995 | |
| 43 | Frank Thomas# | 134 | 1993 | |
| 43 | George Sisler* | 134 | 1922 | |
| 45 | Will Clark# | 133 | 1994 | |
| 45 | John Jaha# | 133 | 1996 | |
| 45 | Mark McGwire# | 133 | 2000 | |
| 45 | Frank Thomas# | 133 | 1996 | |
| 45 | Rafael Palmeiro# | 133 | 1996 | |
| 50 | Ryan Klesko# | 132 | 1999 | |
| 51 | Lu Blue | 131 | 1922 | |
| 51 | Larry Walker# | 131 | 1996 | |
| 53 | Jimmie Foxx* | 130 | 1939 | |
| 53 | Harry Stovey | 130 | 1885 | |
| 53 | Mark McGwire# | 130 | 1995 | |
| 53 | Jimmie Foxx* | 130 | 1936 | |
| 57 | Jason Giambi# | 129 | 1996 | |
| 58 | Paul Konerko# | 128 | 1999 | |
| 58 | Lou Gehrig* | 128 | 1934 | |
| 58 | Rod Carew* | 128 | 1977 | |
| 61 | Derrek Lee# | 127 | 1999 | |
| 61 | Lou Gehrig* | 127 | 1929 | |
| 61 | Jimmie Foxx* | 127 | 1930 | |
| 61 | Jeff Bagwell# | 127 | 1994 | |
| 65 | Todd Helton# | 126 | 2000 | |
| 65 | Larry Walker# | 126 | 1995 | |
| 65 | Paul Konerko# | 126 | 1998 | |
| 65 | Frank Thomas# | 126 | 1997 | |
| 69 | George Sisler* | 125 | 1921 | |
| 69 | Carl Yastrzemski* | 125 | 1970 | |
| 69 | Jose Canseco# | 125 | 1990 | |
| 69 | Fred Tenney | 125 | 1897 | |
| 69 | Todd Helton# | 125 | 1996 | |
| 69 | Jackie Robinson* | 125 | 1947 | |
| 69 | Jimmie Foxx* | 125 | 1933 | |
| 69 | Lou Gehrig* | 125 | 1935 | |
| 77 | Stan Musial* | 124 | 1946 | |
| 77 | Mark McGwire# | 124 | 1992 | |
| 77 | Hal Trosky | 124 | 1936 | |
| 77 | Bill Terry* | 124 | 1932 | |
| 77 | Harry Stovey | 124 | 1884 | |
| 82 | Mark McGwire# | 123 | 1993 | |
| 82 | Jimmie Foxx* | 123 | 1929 | |
| 82 | Roger Connor* | 123 | 1892 | |
| 82 | Jim Bottomley* | 123 | 1928 | |
| 86 | Felipe Alou | 122 | 1966 | |
| 86 | Rusty Greer# | 122 | 1994 | |
| 86 | Ed Morgan | 122 | 1930 | |
| 89 | Dan Brouthers* | 121 | 1892 | |
| 89 | Jake Beckley* | 121 | 1894 | |
| 89 | Bill Terry* | 121 | 1931 | |
| 89 | Kevin Mitchell | 121 | 1993 | |
| 89 | Hank Greenberg* | 121 | 1935 | |
| 94 | Zeke Bonura | 120 | 1936 | |
| 94 | Jimmie Foxx* | 120 | 1934 | |
| 94 | Earl Torgeson | 120 | 1950 | |
| 94 | Frank Thomas# | 120 | 1995 | |
| 94 | Edgar Martinez# | 120 | 1997 | |
| 99 | Jeff Bagwell# | 119 | 1992 | |
| 99 | Jeff Bagwell# | 119 | 1995 |
