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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Mark McGwire# | 204 | 1994 | |
| 2 | Lou Gehrig* | 184 | 1931 | |
| 3 | Hank Greenberg* | 183 | 1937 | |
| 4 | Will Clark# | 181 | 1994 | |
| 5 | Mark McGwire# | 177 | 2000 | |
| 6 | Jason Giambi# | 176 | 1999 | |
| 7 | Jimmie Foxx* | 175 | 1938 | |
| 7 | Lou Gehrig* | 175 | 1927 | |
| 9 | Lou Gehrig* | 174 | 1930 | |
| 10 | Jermaine Dye# | 172 | 2000 | |
| 11 | Jim Thome# | 171 | 1999 | |
| 12 | Hank Greenberg* | 170 | 1935 | |
| 13 | Jimmie Foxx* | 169 | 1932 | |
| 14 | Cliff Floyd# | 167 | 1995 | |
| 15 | Lou Gehrig* | 165 | 1934 | |
| 16 | Rafael Palmeiro# | 164 | 1998 | |
| 17 | Jimmie Foxx* | 163 | 1933 | |
| 18 | Hal Trosky | 162 | 1936 | |
| 19 | Derrek Lee# | 159 | 2000 | |
| 19 | Lou Gehrig* | 159 | 1937 | |
| 21 | Rafael Palmeiro# | 158 | 1995 | |
| 22 | Jimmie Foxx* | 156 | 1930 | |
| 23 | Frank Thomas# | 153 | 1994 | |
| 23 | Jason Giambi# | 153 | 2000 | |
| 25 | Lou Gehrig* | 152 | 1936 | |
| 25 | Frank Thomas# | 152 | 1997 | |
| 27 | John Olerud# | 151 | 1997 | |
| 27 | Lou Gehrig* | 151 | 1932 | |
| 29 | Mark McGwire# | 149 | 1996 | |
| 30 | Cap Anson* | 147 | 1886 | |
| 30 | Frank Thomas# | 147 | 1996 | |
| 32 | Larry Walker# | 146 | 1996 | |
| 32 | Hank Greenberg* | 146 | 1938 | |
| 34 | Derrek Lee# | 145 | 1998 | |
| 34 | Don Mattingly# | 145 | 1985 | |
| 36 | Todd Helton# | 144 | 1996 | |
| 36 | Jeff Bagwell# | 144 | 1994 | |
| 36 | Walt Dropo | 144 | 1950 | |
| 39 | Don Hurst | 143 | 1932 | |
| 39 | Don Mattingly# | 143 | 1989 | |
| 39 | Jimmie Foxx* | 143 | 1936 | |
| 42 | Lou Gehrig* | 142 | 1928 | |
| 42 | Orlando Cepeda | 142 | 1961 | |
| 42 | Hal Trosky | 142 | 1934 | |
| 45 | Paul Konerko# | 141 | 1998 | |
| 45 | Jim Gentile | 141 | 1961 | |
| 45 | Ted Kluszewski | 141 | 1954 | |
| 48 | Don Mattingly# | 140 | 1991 | |
| 48 | John Olerud# | 140 | 1996 | |
| 48 | Andres Galarraga# | 140 | 1996 | |
| 48 | Jeff Bagwell# | 140 | 1995 | |
| 48 | Orlando Merced# | 140 | 1993 | |
| 53 | Frank Thomas# | 139 | 1998 | |
| 53 | Hank Greenberg* | 139 | 1934 | |
| 53 | Lou Gehrig* | 139 | 1933 | |
| 53 | Will Clark# | 139 | 1996 | |
| 57 | Johnny Mize* | 138 | 1947 | |
| 57 | Zeke Bonura | 138 | 1936 | |
| 57 | Rafael Palmeiro# | 138 | 1996 | |
| 60 | Jim Bottomley* | 137 | 1929 | |
| 60 | Richie Sexson# | 137 | 1999 | |
| 60 | Johnny Mize* | 137 | 1940 | |
| 60 | Rafael Palmeiro# | 137 | 1990 | |
| 60 | Dale Alexander | 137 | 1929 | |
| 65 | Paul Konerko# | 136 | 1999 | |
| 65 | Jim Bottomley* | 136 | 1928 | |
| 65 | Ed Morgan | 136 | 1930 | |
| 65 | Don Mattingly# | 136 | 1988 | |
| 65 | George Kelly* | 136 | 1924 | |
| 70 | Larry Walker# | 135 | 1995 | |
| 70 | Dale Alexander | 135 | 1930 | |
| 70 | Matt Williams# | 135 | 1994 | |
| 73 | Rudy York | 134 | 1940 | |
| 73 | Mark McGwire# | 134 | 1997 | |
| 75 | Frank Thomas# | 133 | 1992 | |
| 76 | Norm Cash | 132 | 1961 | |
| 76 | Edgar Martinez# | 132 | 1996 | |
| 76 | Don Mattingly# | 132 | 1993 | |
| 76 | Mark McGwire# | 132 | 1991 | |
| 80 | Jimmie Foxx* | 130 | 1934 | |
| 80 | Jack Fournier | 130 | 1925 | |
| 80 | Roger Connor* | 130 | 1889 | |
| 80 | Kevin Mitchell | 130 | 1992 | |
| 80 | Gil Hodges | 130 | 1954 | |
| 85 | Bill Terry* | 129 | 1930 | |
| 86 | Dan Brouthers* | 128 | 1894 | |
| 86 | Hal Trosky | 128 | 1937 | |
| 86 | Frank McCormick | 128 | 1939 | |
| 86 | Jim Bottomley* | 128 | 1925 | |
| 86 | Don Mattingly# | 128 | 1992 | |
| 86 | Tino Martinez# | 128 | 2000 | |
| 86 | Ripper Collins | 128 | 1934 | |
| 93 | Jimmie Foxx* | 127 | 1937 | |
| 93 | John Jaha# | 127 | 1996 | |
| 93 | Edgar Martinez# | 127 | 1994 | |
| 93 | Will Clark# | 127 | 1993 | |
| 93 | Hank Greenberg* | 127 | 1946 | |
| 93 | Frank McCormick | 127 | 1940 | |
| 93 | Nap Lajoie* | 127 | 1897 | |
| 100 | Willie McCovey* | 126 | 1970 |
