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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Pedro Martinez# | 10.58 | 1991-2001 | |
| 2 | Bob Gibson* | 10.22 | 1959-1975 | |
| 3 | Nolan Ryan* | 9.74 | 1966-1992 | |
| 4 | Scott Williamson# | 9.68 | 1997-2001 | |
| 5 | Sandy Koufax* | 9.63 | 1955-1966 | |
| 6 | Chan-ho Park# | 9.20 | 1994-2001 | |
| 7 | Mark Langston | 8.90 | 1984-1999 | |
| 8 | Jeff Fassero | 8.62 | 1988-2000 | |
| 9 | Randy Johnson# | 8.53 | 1988-2001 | |
| 10 | Javier Vazquez# | 8.36 | 1998-2001 | |
| 11 | Rich Gossage* | 8.33 | 1972-1993 | |
| 12 | Tug McGraw | 8.25 | 1965-1984 | |
| 13 | Roger Clemens# | 8.18 | 1984-2001 | |
| 14 | Don Drysdale* | 8.17 | 1956-1969 | |
| 15 | Greg Maddux# | 8.08 | 1986-2001 | |
| 16 | Mike Morgan | 8.07 | 1978-1999 | |
| 17 | George Earnshaw | 8.04 | 1928-1936 | |
| 18 | Miguel Batista# | 8.02 | 1993-2001 | |
| 19 | Sid Fernandez | 7.87 | 1983-1999 | |
| 20 | Frank Viola | 7.74 | 1982-1998 | |
| 21 | Bob Turley | 7.71 | 1951-1963 | |
| 22 | Darryl Kile# | 7.70 | 1989-2001 | |
| 23 | Steve Carlton* | 7.61 | 1965-1988 | |
| 24 | Carl Pavano# | 7.47 | 1995-2001 | |
| 25 | Tom Seaver* | 7.44 | 1967-1986 | |
| 26 | Aaron Sele# | 7.36 | 1991-2001 | |
| 27 | Pedro Astacio# | 7.33 | 1992-2001 | |
| 28 | John Clarkson* | 7.31 | 1882-1894 | |
| 28 | Ron Reed | 7.31 | 1966-1984 | |
| 30 | Ron Darling | 7.29 | 1983-1997 | |
| 31 | Allie Reynolds | 7.22 | 1942-1954 | |
| 32 | Bill Dinneen | 7.20 | 1898-1909 | |
| 32 | Alex Fernandez# | 7.20 | 1990-2001 | |
| 34 | Robb Nen# | 7.18 | 1990-2001 | |
| 35 | Max Lanier | 7.11 | 1938-1953 | |
| 36 | Ron Guidry | 7.10 | 1975-1990 | |
| 37 | Darren Oliver# | 7.08 | 1990-2001 | |
| 38 | Monte Pearson | 7.07 | 1932-1941 | |
| 39 | Rollie Fingers* | 7.06 | 1968-1985 | |
| 40 | Mort Cooper | 7.00 | 1938-1949 | |
| 40 | Antonio Osuna# | 7.00 | 1994-2001 | |
| 42 | Don Robinson | 6.95 | 1978-1996 | |
| 43 | Andy Pettitte# | 6.94 | 1992-2001 | |
| 44 | Greg Swindell# | 6.93 | 1986-2000 | |
| 44 | Jose Lima# | 6.93 | 1993-2001 | |
| 46 | Jerry Koosman | 6.92 | 1967-1985 | |
| 47 | John Candelaria | 6.90 | 1975-1991 | |
| 48 | Jack Billingham | 6.86 | 1968-1980 | |
| 49 | Al Leiter# | 6.85 | 1987-2001 | |
| 49 | Bob Welch | 6.85 | 1978-1994 | |
| 49 | Bert Blyleven* | 6.85 | 1970-1990 | |
| 52 | Jose Rijo# | 6.82 | 1984-2000 | |
| 53 | John Smoltz# | 6.81 | 1988-2001 | |
| 54 | Jeff Suppan# | 6.79 | 1995-2001 | |
| 54 | Tim Keefe* | 6.79 | 1880-1893 | |
| 56 | Carl Erskine | 6.70 | 1948-1959 | |
| 57 | Bruce Kison | 6.69 | 1971-1985 | |
| 58 | Dwight Gooden# | 6.68 | 1984-2000 | |
| 59 | Danny Cox | 6.66 | 1983-1994 | |
| 60 | Kenny Rogers# | 6.64 | 1989-2001 | |
| 61 | John Tudor | 6.63 | 1979-1996 | |
| 62 | Mike Hampton# | 6.60 | 1993-2001 | |
| 63 | Todd Worrell | 6.59 | 1985-1997 | |
| 64 | Rick Aguilera | 6.57 | 1985-1999 | |
| 65 | John Franco# | 6.55 | 1984-2001 | |
| 65 | Jack Morris | 6.55 | 1977-1997 | |
| 67 | Vida Blue | 6.54 | 1969-1986 | |
| 68 | Jim Palmer* | 6.51 | 1965-1984 | |
| 69 | Charlie Hough | 6.50 | 1970-1992 | |
| 70 | John Smiley# | 6.49 | 1986-2001 | |
| 71 | Dave McNally | 6.48 | 1962-1975 | |
| 72 | Steve Blass | 6.42 | 1964-1974 | |
| 73 | Vic Raschi | 6.41 | 1946-1955 | |
| 73 | Red Ruffing* | 6.41 | 1924-1947 | |
| 75 | Jim Abbott# | 6.33 | 1989-2001 | |
| 76 | Lefty Grove* | 6.31 | 1925-1941 | |
| 77 | Walter Johnson* | 6.30 | 1907-1927 | |
| 78 | Charles Bender* | 6.25 | 1903-1925 | |
| 79 | Steve Avery# | 6.24 | 1989-2001 | |
| 79 | Ben McDonald# | 6.24 | 1989-2001 | |
| 81 | Kevin Brown# | 6.14 | 1986-2001 | |
| 81 | Orval Overall | 6.14 | 1905-1913 | |
| 83 | Bill Hallahan | 6.13 | 1925-1938 | |
| 83 | Blue Moon Odom | 6.13 | 1964-1976 | |
| 85 | Chris Carpenter# | 6.12 | 1995-2001 | |
| 85 | Clay Carroll | 6.12 | 1964-1978 | |
| 87 | Fernando Valenzuela | 6.07 | 1980-1999 | |
| 87 | Grover Cleveland Alexander* | 6.07 | 1911-1930 | |
| 87 | Mickey Lolich | 6.07 | 1963-1979 | |
| 87 | Ralph Terry | 6.07 | 1956-1967 | |
| 91 | Mark Gubicza | 6.03 | 1984-1997 | |
| 91 | Bobby Thigpen# | 6.03 | 1986-2001 | |
| 93 | Don Larsen | 6.00 | 1953-1967 | |
| 93 | Dave Righetti | 6.00 | 1979-1996 | |
| 95 | Pat Combs# | 5.97 | 1990-1999 | |
| 96 | David Cone# | 5.95 | 1986-2001 | |
| 97 | Bill Donovan | 5.94 | 1898-1918 | |
| 98 | Bruce Hurst | 5.92 | 1980-1992 | |
| 99 | Mike Cuellar | 5.91 | 1959-1977 | |
| 100 | Chris Haney# | 5.81 | 1991-2001 |
