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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | RBI | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Mark McGwire# | 204 | 1994 | |
| 2 | Hack Wilson* | 191 | 1930 | |
| 3 | Lou Gehrig* | 184 | 1931 | |
| 4 | Hank Greenberg* | 183 | 1937 | |
| 5 | Will Clark# | 181 | 1994 | |
| 6 | Carlos Lee# | 178 | 1999 | |
| 7 | Mark McGwire# | 177 | 2000 | |
| 8 | Jason Giambi# | 176 | 1999 | |
| 9 | Jimmie Foxx* | 175 | 1938 | |
| 9 | Lou Gehrig* | 175 | 1927 | |
| 11 | Lou Gehrig* | 174 | 1930 | |
| 11 | Gary Sheffield# | 174 | 1995 | |
| 11 | Rafael Palmeiro# | 174 | 1999 | |
| 14 | Jermaine Dye# | 172 | 2000 | |
| 14 | Ken Griffey Jr.# | 172 | 1996 | |
| 16 | Jim Thome# | 171 | 1999 | |
| 16 | Babe Ruth* | 171 | 1921 | |
| 18 | Chuck Klein* | 170 | 1930 | |
| 18 | Sammy Sosa# | 170 | 1998 | |
| 18 | Hank Greenberg* | 170 | 1935 | |
| 21 | Jimmie Foxx* | 169 | 1932 | |
| 22 | Albert Belle# | 168 | 2000 | |
| 23 | Cliff Floyd# | 167 | 1995 | |
| 23 | Rico Brogna# | 167 | 1997 | |
| 23 | Barry Bonds# | 167 | 1995 | |
| 23 | Joe DiMaggio* | 167 | 1937 | |
| 27 | Sam Thompson* | 166 | 1887 | |
| 28 | Sam Thompson* | 165 | 1895 | |
| 28 | David Justice# | 165 | 1999 | |
| 28 | Al Simmons* | 165 | 1930 | |
| 28 | Lou Gehrig* | 165 | 1934 | |
| 28 | Rico Brogna# | 165 | 1996 | |
| 33 | Babe Ruth* | 164 | 1927 | |
| 33 | Rafael Palmeiro# | 164 | 1998 | |
| 35 | Jimmie Foxx* | 163 | 1933 | |
| 35 | Babe Ruth* | 163 | 1931 | |
| 37 | Hal Trosky | 162 | 1936 | |
| 38 | Vern Stephens | 159 | 1949 | |
| 38 | Derrek Lee# | 159 | 2000 | |
| 38 | Lou Gehrig* | 159 | 1937 | |
| 38 | Ted Williams* | 159 | 1949 | |
| 38 | Hack Wilson* | 159 | 1929 | |
| 43 | Rafael Palmeiro# | 158 | 1995 | |
| 44 | Al Simmons* | 157 | 1929 | |
| 45 | Cliff Floyd# | 156 | 1998 | |
| 45 | Jimmie Foxx* | 156 | 1930 | |
| 47 | Joe DiMaggio* | 155 | 1948 | |
| 47 | Ken Williams | 155 | 1922 | |
| 47 | Russell Branyan# | 155 | 2000 | |
| 47 | Barry Bonds# | 155 | 1994 | |
| 51 | Alfonso Soriano# | 154 | 1999 | |
| 51 | Joe Medwick* | 154 | 1937 | |
| 51 | Babe Ruth* | 154 | 1929 | |
| 54 | Tommy Davis | 153 | 1962 | |
| 54 | Jason Giambi# | 153 | 2000 | |
| 54 | Frank Thomas# | 153 | 1994 | |
| 54 | Moises Alou# | 153 | 1994 | |
| 54 | Shawn Green# | 153 | 1996 | |
| 54 | Babe Ruth* | 153 | 1930 | |
| 60 | Rondell White# | 152 | 1996 | |
| 60 | Rogers Hornsby* | 152 | 1922 | |
| 60 | David Justice# | 152 | 1996 | |
| 60 | Frank Thomas# | 152 | 1997 | |
| 60 | Lou Gehrig* | 152 | 1936 | |
| 65 | John Olerud# | 151 | 1997 | |
| 65 | David Justice# | 151 | 1998 | |
| 65 | Al Simmons* | 151 | 1932 | |
| 65 | Mel Ott* | 151 | 1929 | |
| 65 | Lou Gehrig* | 151 | 1932 | |
| 70 | Gary Sheffield# | 150 | 1996 | |
| 70 | Babe Ruth* | 150 | 1926 | |
| 70 | Raul Mondesi# | 150 | 1995 | |
| 70 | Hank Greenberg* | 150 | 1940 | |
| 70 | Alex Rodriguez# | 150 | 2000 | |
| 70 | Ken Griffey Jr.# | 150 | 1998 | |
| 76 | Brian Giles# | 149 | 1996 | |
| 76 | Jose Cruz Jr.# | 149 | 1999 | |
| 76 | Manny Ramirez# | 149 | 1999 | |
| 76 | Mark McGwire# | 149 | 1996 | |
| 76 | George Foster | 149 | 1977 | |
| 76 | Ken Griffey Jr.# | 149 | 1997 | |
| 76 | Rogers Hornsby* | 149 | 1929 | |
| 76 | Eddie Murray | 149 | 1996 | |
| 84 | Moises Alou# | 148 | 1999 | |
| 84 | Luis Gonzalez# | 148 | 1993 | |
| 84 | Johnny Bench* | 148 | 1970 | |
| 87 | Frank Thomas# | 147 | 1996 | |
| 87 | Cap Anson* | 147 | 1886 | |
| 87 | Ken Griffey Jr.# | 147 | 1999 | |
| 90 | Brian Giles# | 146 | 1995 | |
| 90 | Alex Rodriguez# | 146 | 1996 | |
| 90 | Larry Walker# | 146 | 1996 | |
| 90 | Ed Delahanty* | 146 | 1893 | |
| 90 | Hank Greenberg* | 146 | 1938 | |
| 90 | Shawn Green# | 146 | 2000 | |
| 96 | Ted Williams* | 145 | 1939 | |
| 96 | Bo Jackson# | 145 | 1993 | |
| 96 | Don Mattingly# | 145 | 1985 | |
| 96 | Derrek Lee# | 145 | 1998 | |
| 96 | Hugh Duffy* | 145 | 1894 |
